For Physicians


Other Pipeline

In addition to our product candidates custirsen in Phase 3 development, and apatorsen (OGX-427) in Phase 2 development, our investigational compound OGX-225 is in pre-clinical development.

OGX-225 is a second generation antisense drug candidate designed to inhibit the production of Insulin Growth Factor Binding Proteins -2 and -5 (IGFBP-2, IGFBP-5), two proteins that when overexpressed affect the growth of cancer cells.

    • Increased IGFBP-2 and IGFBP-5 production are observed in many human cancers, including prostate, breast, colorectal, non-small cell lung, glioblastoma, acute myeloid leukemia, acute lymphoblastic leukemia, neuroblastoma, and melanoma.

    • Increased IGFBP-2 and IGFBP-5 production are linked to faster rates of cancer progression, treatment resistance, and shorter survival duration in humans.

    • Preclinical studies with human prostate and breast cancer cells have shown that reducing IGFBP-2 and IGFBP-5 production with OGX-225 sensitized these tumor types to hormone ablation therapy or chemotherapy and induced tumor cell death.

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